.svg)
.svg)
Startle PPI 3.0
Acoustic startle and pre-pulse inhibition (PPI) testing system for rodents. Supports up to 4 simultaneous test chambers with a calibrated sound range of 65–120 dB, driven by Windows 64-bit software for automated data acquisition and analysis.
Startle PPI 3.0
The Startle PPI 3.0 (Pre-Pulse Inhibition of Startle Reflex) by Ugo Basile is an advanced acoustic startle system designed to measure acoustic startle responses and pre-pulse inhibition in rodents. The system delivers precisely calibrated acoustic stimuli and quantifies the startle reflex — a fundamental readout for sensorimotor gating research.
Widely used in neuropharmacology and psychiatric disorder research, the Startle PPI 3.0 can simultaneously run up to 4 independent chambers, each with its own calibrated speaker and sensor, all managed by a single Windows 64-bit software package.
Key Features
- Broad sound range of 65–120 dB for precise stimulus control
- Supports up to 4 simultaneous test chambers
- Windows 64-bit compatible software
- Accurate startle response quantification
- Suitable for both mice and rats
.webp)
Research Applications
The Startle PPI 3.0 is a fundamental tool in neuroscience research for studying sensorimotor gating — the brain's ability to filter irrelevant sensory information. Pre-pulse inhibition deficits are among the most robust neurobiological findings in schizophrenia research, and the test is widely used to evaluate the effects of antipsychotic drugs.
- Schizophrenia models: Evaluating PPI deficits induced by dopaminergic or glutamatergic compounds
- Drug screening: Antipsychotic, anxiolytic, and cognitive enhancer profiling
- Genetic models: Phenotyping transgenic and knockout mice for sensorimotor gating deficits
- Anxiety research: Measuring baseline startle reactivity as an anxiety biomarker
- Neurodevelopmental disorders: Autism spectrum disorder and ADHD models
Memory and Learning
Explore All ProductsWhat does pre-pulse inhibition (PPI) measure?
PPI measures sensorimotor gating — the brain's ability to suppress its startle response when preceded by a softer warning stimulus. Deficits in PPI are neurobiological biomarkers for schizophrenia and other psychiatric disorders.
How many animals can be tested simultaneously?
The Startle PPI 3.0 supports up to 4 simultaneous test chambers, each with its own calibrated speaker and startle sensor, managed by a single Windows 64-bit software package.
What sound range does the system support?
The system delivers acoustic stimuli across a range of 65–120 dB, enabling precise control of background noise levels and both pre-pulse and pulse intensities.
Is the system suitable for both mice and rats?
Yes, the Startle PPI 3.0 is available in configurations for both mice and rats, with appropriately sized restrainers and calibrated transducers for each species.
What research areas does PPI testing support?
PPI testing supports schizophrenia, autism spectrum disorder, ADHD, and anxiety research. It is also widely used for pharmacological profiling of antipsychotic and anxiolytic drugs.
Still have questions?
Request for Quote
Please fill in as much details as possible and we will take care of your request as soon as possible
Request for Quote
Please fill in as much details as possible and we will take care of your request as soon as possible