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R811/FR-11 Dual Color Multichannel Fiber Photometry System
The RWD R811/FR-11 is a dual-channel fiber photometry system optimized for green fluorescent indicators (GCaMP, dLight, GRAB sensors) with an isosbestic 410 nm reference for artifact-free recordings. Supporting up to 9 simultaneous channels, it delivers high-sensitivity neural activity monitoring in freely behaving animals with no programming required.
What is the R811/FR-11 Dual Color Multichannel Fiber Photometry System?
The RWD R811/FR-11 Dual Color Multichannel Fiber Photometry System is an in vivo optical recording platform for monitoring calcium dynamics and neurotransmitter activity in freely behaving animals using green fluorescent indicators. Combining a 410 nm isosbestic reference channel with 470 nm excitation, it records signals from GCaMP, dLight, and other green indicators across up to 9 simultaneous channels, while continuously correcting for motion artifacts and photobleaching noise.
Powered by professional acquisition and analysis software requiring no Matlab expertise, the R811 is an accessible yet high-performance solution for neural circuit researchers who work primarily with green GECIs. It includes a built-in optogenetics interface and supports a comprehensive suite of acquisition modes.
Key Features
- Dual Channel (410/470 nm): Isosbestic 410 nm reference corrects for motion and bleaching artifacts; 470 nm excites GCaMP, dLight, and green neurotransmitter probes with picowatt-level sensitivity.
- Up to 9 Simultaneous Channels: Record from multiple animals or multiple brain regions in a single experimental session.
- Highly Sensitive Detectors: Independent and sequential detection eliminates channel cross-talk and provides accurate signal measurement at weak signal levels.
- No Programming Required: Built-in analysis software handles ΔF/F, Z-score, peri-event heatmaps, bleaching correction, behavior trajectory overlay, and data export without coding.
- Five Acquisition Modes: Continuous, interval, triggered, delayed, and timed acquisition with live ΔF/F monitoring.
- Built-In Optogenetic Interface: Supports synchronized stimulation and recording at the same brain site, compatible with RWD and third-party optogenetics systems.
- 4×4 Digital I/O: Four digital inputs and outputs for TTL-based synchronization with electrophysiology systems, behavioral cameras, and external devices.
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Technical Specifications
| Catalog Number | R811 / FR-11 (US) |
| Excitation Wavelengths | 410 nm (reference), 470 nm (green) |
| Compatible Indicators | GCaMP, dLight, green neurotransmitter probes (dopamine, ACh, serotonin) |
| Power Output | 0 – ≥200 µW, adjustable, 0.1 µW precision |
| Number of Channels | Up to 9 |
| Frame Rate | Max 250 fps |
| Digital Signal Interface | 4 Input + 4 Output |
| Signal Output | 0–500 Hz; adjustable pulse width and duration |
| Behavior Camera | 1920×1080 @ 30 fps / 1280×720 @ 60 fps |
| Acquisition Modes | Continuous, interval, triggered, delayed, timing |
| Optogenetics Integration | Built-in interface for same-site stimulation and recording |
Applications
- Calcium imaging with GCaMP in freely moving rodents
- Dopamine, acetylcholine, and serotonin release monitoring with GRAB sensors
- Closed-loop fiber photometry + optogenetics
- Multi-animal behavioral neuroscience experiments
- Learning, memory, addiction, and anxiety research
Fiber Photometry
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Explore All ProductsR811 Dual Color Fiber Photometry System Publications
The RWD R811 Dual Color Multichannel Fiber Photometry System is widely used in behavioral neuroscience publications recording GCaMP fluorescence from genetically targeted neurons in freely behaving mice and rats. Studies span topics from dopamine dynamics and fear conditioning to sleep and circadian regulation.
What is the 410 nm channel for?
It is the isosbestic reference. At 410 nm the indicator fluoresces independently of calcium, so that trace carries the motion and bleaching artefact without the signal. Subtract it from the 470 nm trace and what is left is the calcium response.
Which indicators does the R811 cover?
The green ones. GCaMP, dLight, and the green neurotransmitter sensors for dopamine, acetylcholine and serotonin. For red indicators such as RCaMP or jrGECO1a you need the R812, and for both colours at once the R821.
How many animals or regions can I record at once?
Up to 9 channels at up to 250 fps. That covers several implants in one animal or several animals in one session.
Do I need Matlab to analyse the data?
No. The bundled software does delta F over F, Z-score, peri-event heatmaps, bleaching correction and behaviour trajectory overlay, and exports from there.
Can I run optogenetics at the same site?
Yes. There is a built-in optogenetics interface, plus four digital inputs and four outputs at 0 to 500 Hz for TTL synchronisation with electrophysiology and behavioural hardware. NBT is the RWD distributor in Israel.
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