What is the R811/FR-11 Dual Color Multichannel Fiber Photometry System?

The RWD R811/FR-11 Dual Color Multichannel Fiber Photometry System is an in vivo optical recording platform for monitoring calcium dynamics and neurotransmitter activity in freely behaving animals using green fluorescent indicators. Combining a 410 nm isosbestic reference channel with 470 nm excitation, it records signals from GCaMP, dLight, and other green indicators across up to 9 simultaneous channels — while continuously correcting for motion artifacts and photobleaching noise.

Powered by professional acquisition and analysis software requiring no Matlab expertise, the R811 is an accessible yet high-performance solution for neural circuit researchers who work primarily with green GECIs. It includes a built-in optogenetics interface and supports a comprehensive suite of acquisition modes.

Key Features

• Dual Channel (410/470 nm): Isosbestic 410 nm reference corrects for motion and bleaching artifacts; 470 nm excites GCaMP, dLight, and green neurotransmitter probes with picowatt-level sensitivity.
• Up to 9 Simultaneous Channels: Record from multiple animals or multiple brain regions in a single experimental session.
• Highly Sensitive Detectors: Independent and sequential detection eliminates channel cross-talk and provides accurate signal measurement at weak signal levels.
• No Programming Required: Built-in analysis software handles ΔF/F, Z-score, peri-event heatmaps, bleaching correction, behavior trajectory overlay, and data export without coding.
• Five Acquisition Modes: Continuous, interval, triggered, delayed, and timed acquisition with live ΔF/F monitoring.
• Built-In Optogenetic Interface: Supports synchronized stimulation and recording at the same brain site, compatible with RWD and third-party optogenetics systems.
• 4×4 Digital I/O: Four digital inputs and outputs for TTL-based synchronization with electrophysiology systems, behavioral cameras, and external devices.