What is the PV850 Pressure Microinjector?

The PV850 is a precision pressure microinjector from World Precision Instruments (WPI) designed for reliable delivery of fluids into live tissue — from individual cells to targeted brain regions. Delivering volumes ranging from picoliters to nanoliters, the PV850 connects to any existing external pressure source and offers independent, touchscreen-controlled regulation of injection pressure, compensation pressure, and pulse timing. It is the go-to instrument for researchers performing stereotaxic viral vector delivery, in vivo drug injection, zebrafish and embryo microinjection, and intracellular injection of DNA, RNA, and proteins.

The PV850 is part of WPI's new generation of pressure microinjectors and is distinguished by its flexible compatibility with external pressure supplies — making it a cost-effective integration into labs that already operate compressed air or regulated pressure lines. Its Narishige and TransferMan NK2-compatible capillary holder ensures seamless integration with the most widely used micromanipulation systems in life science research.

Key Features

• External Pressure Source Compatible: Connects to any existing lab pressure line or regulated compressed air supply, making the PV850 an affordable, flexible entry point into precision pressure microinjection without sacrificing performance or accuracy.
• Touchscreen Control: Injection pressure, compensation pressure, and pulse timing are independently adjusted via an intuitive touchscreen interface — providing precise, repeatable control over every injection parameter.
• Dual Pressure Regulation: Separate injection and compensation (backfill prevention) pressures are maintained with a precision timing circuit that automatically switches between them between pulses, preventing capillary back-filling and ensuring consistent delivered volumes.
• Picoliter–Nanoliter Volume Range: Delivers highly controlled fluid volumes from picoliters to nanoliters, suitable for intracellular injection, stereotaxic brain delivery, zebrafish and rodent embryo microinjection.
• Foot Switch Trigger: Hands-free injection activation via a heavy-duty foot switch allows the researcher to stay focused on the microscope or stereotaxic frame throughout the procedure.
• Narishige & TransferMan-Compatible: Includes a Narishige and TransferMan NK2-compatible capillary holder out of the box, enabling immediate integration with the most widely used micromanipulation platforms in life science labs.
• Precision Timing: Time intervals are programmable from 2 seconds down to 10 ms (or less, depending on pressure setting), giving researchers fine control over bolus size and delivery rate.