MOD-multiclamp700B
Cell Neurobiology & Imaging

Patch Clamp Amplifiers

The Axon Instruments® series of amplifiers provide best-in-class solutions for the entire range of patch-clamp experiments. The portfolio of amplifiers includes Axopatch™ 200B for ultra low-noise single-channel recordings, MultiClamp™ 700B for whole-cell voltage-clamp and high-speed current-clamp recordings, and Axoclamp™ 900A for two-electrode voltage-clamp and current-clamp recordings.

Patch Clamp Amplifiers

Patch-clamp amplifiers from single channels to large macroscopic recordings

The Axon Instruments® series of amplifiers provide best-in-class solutions for the entire range of patch-clamp experiments. The portfolio of amplifiers includes Axopatch™ 200B for ultra low-noise single-channel recordings, MultiClamp™ 700B for whole-cell voltage-clamp and high-speed current-clamp recordings, and Axoclamp™ 900A for two-electrode voltage-clamp and current-clamp recordings.

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Maximize signal to noise ratio

The Axopatch 200B Capacitor Feedback Patch Clamp Amplifier offers one of the lowest-noise single-channel recordings available via innovative capacitor-feedback technology.

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Perform multi-channel experiments

The MultiClamp 700B Microelectrode Amplifier enables whole-cell voltage-clamp and current-clamp recordings. It is the most versatile amplifier in the portfolio.

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Measure large currents

Large output compliance range of our Axoclamp 900A Microelectrode Amplifier facilitates the measurement of large and rapid voltage-clamp and current-clamp recordings.

Features

Environmental Control Icon

Actively cooled headstage

The Axopatch 200B amplifier features proprietary technology that provides active headstage cooling that reduces electrical noise close to the theoretical limits of physics.

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Software control of settings

The MultiClamp 700B and Axoclamp 900A amplifiers offer software control. Software control streamlines setup, and enables automation of parameters, telegraphing, and advanced protocols.

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Support up to four headstages

The MultiClamp 700B supports up to two primary CV-7B headstages and two optional auxiliary headstages (HS-2 or VG-2 type) enabling multi-channel recording for cellular network studies.

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Large output compliance range

The Axoclamp 900A amplifier supports the measurement of larger currents and ensures faster clamp speed (±180 V in TEVC and HVIC modes).

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Multiple modes of operation

The Axoclamp 900A amplifier offers 5 modes of operation: current clamp, discontinuous current clamp, two-electrode voltage clamp, discontinuous single-electrode voltage clamp, high-voltage current clamp.

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Works with any data acquisition system

The family of amplifiers integrates with most data acquisition programs. The pCLAMP™ 11 Software and DigiData® 1550B system for data acquisition and analysis provide optimal performance.

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Axopatch 200B Capacitor Feedback Patch Clamp AmplifierRequest a Quote MultiClamp 700B Microelectrode AmplifierRequest a Quote Axoclamp 900A Microelectrode AmplifierRequest a Quote
General specifications
Applications Single-channel recording, whole-cell patch-clamp recording, extracellular recording, amperometry/voltammetry, bilayer recording, nanopore study Single-channel recording, whole-cell patch-clamp recording, intracelluar sharp electrode recording, extracellular recording, amperometry/voltammetry, bilayer recording, nanopore study Whole-cell current-clamp recording, intracelluar sharp electrode recording, extracellular recording, two-electrode voltage-clamp recording
Smart telegraph Gain, filter, capacitance Gain, filter, capacitance, input/output scaling factors, recording mode - 2 channels Gain, filter, capacitance, input/output scaling factors, recording mode - 2 channels
Seal test YES YES YES
Holding potential range -/+ 1000 mV -/+ 1000 mV -/+ 200 mV for dSEVC and TEVC modes
Holding current range -/+ 200 nA -/+ 200 nA Up to -/+ 1/Ro (feedback resistor)
Output gain (mV/pA) 0.5 to 500 1.0 to 2000 1.0 to 2000
Modes I-Clamp, V-Clamp I-Clamp, V-Clamp I-Clamp, DCC, HVIC, dSEVC, TEVC
Open circuit noise in 5kHz and 10 kHz 0.06 pA rms, (5 kHz), 0.13 pA rms (10 kHz) 0.15 pA rms, (5 kHz), 0.28 pA rms (10 kHz) NO
True voltage clamp-resistor feedback YES for cSEVC YES for cSEVC YES for dSEVC
Capacitance Compensation YES YES YES
RMS noise 0.13 pA rms (10 kHz) increases to only 0.145 pA RMS when a patch-pipette holder is attached 0.28 pA rms (10 kHz) at 50 GΩ to 3.0 pA rms (10 kHz) at 50 MΩ 20 mV at 10 kHz
Automatic oscillation suppression NO YES YES
Automated mode-switching between current clamp and voltage clamp mode NO YES YES
Slow current injection to maintain assigned potential NO YES YES
True current clamp-voltage follower NO YES YES
Simultaneous dual patch clamping recordings NO YES YES
Computer control* NO YES YES
Conventional interface YES YES YES

Patch Clamp Techniques

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Electro-Physiology

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Molecular Devices

Academic publications and research studies utilizing Molecular Devices patch clamp instruments, sourced from Google Scholar.

What is the Patch Clamp Amplifiers and what is it used for?

The Axon Instruments® series of amplifiers provide best-in-class solutions for the entire range of patch-clamp experiments. The portfolio of amplifiers includes Axopatch™ 200B for ultra low-noise sing.

What research applications is the Patch Clamp Amplifiers suited for?

The Patch Clamp Amplifiers is suited for researchers in neuroscience, behavioral science, physiology, and related life science fields. It is designed to support experimental workflows that require reliable, high-quality data acquisition and analysis.

What are the key technical features of the Patch Clamp Amplifiers?

The Patch Clamp Amplifiers (catalog number: MOD-multiclamp700B) is engineered for precision performance in laboratory settings. It offers user-friendly operation, robust construction, and compatibility with standard laboratory workflows to maximize experimental efficiency and reproducibility.

Is the Patch Clamp Amplifiers available in Israel with local support?

Yes. NBT Ltd is the exclusive distributor of this product in Israel. Our team of scientific specialists provides full local support including installation, application training, and ongoing technical assistance for the Patch Clamp Amplifiers.

What accessories or systems is the Patch Clamp Amplifiers compatible with?

The Patch Clamp Amplifiers is designed to integrate seamlessly with complementary laboratory instruments and software used in its application domain. NBT Ltd can advise on compatible accessories, consumables, and system configurations to meet your specific research needs.

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