Patch-clamp amplifiers from single channels to large macroscopic recordings

The Axon Instruments^® series of amplifiers provide best-in-class solutions for the entire range of patch-clamp experiments. The portfolio of amplifiers includes Axopatch™ 200B for ultra low-noise single-channel recordings, MultiClamp™ 700B for whole-cell voltage-clamp and high-speed current-clamp recordings, and Axoclamp™ 900A for two-electrode voltage-clamp and current-clamp recordings.

Maximize signal to noise ratio

The Axopatch 200B Capacitor Feedback Patch Clamp Amplifier offers one of the lowest-noise single-channel recordings available via innovative capacitor-feedback technology.

Perform multi-channel experiments

The MultiClamp 700B Microelectrode Amplifier enables whole-cell voltage-clamp and current-clamp recordings. It is the most versatile amplifier in the portfolio.

Measure large currents

Large output compliance range of our Axoclamp 900A Microelectrode Amplifier facilitates the measurement of large and rapid voltage-clamp and current-clamp recordings.

Features

Actively cooled headstage

The Axopatch 200B amplifier features proprietary technology that provides active headstage cooling that reduces electrical noise close to the theoretical limits of physics.

Software control of settings

The MultiClamp 700B and Axoclamp 900A amplifiers offer software control. Software control streamlines setup, and enables automation of parameters, telegraphing, and advanced protocols.

Support up to four headstages

The MultiClamp 700B supports up to two primary CV-7B headstages and two optional auxiliary headstages (HS-2 or VG-2 type) enabling multi-channel recording for cellular network studies.

Large output compliance range

The Axoclamp 900A amplifier supports the measurement of larger currents and ensures faster clamp speed (±180 V in TEVC and HVIC modes).

Multiple modes of operation

The Axoclamp 900A amplifier offers 5 modes of operation: current clamp, discontinuous current clamp, two-electrode voltage clamp, discontinuous single-electrode voltage clamp, high-voltage current clamp.

Works with any data acquisition system

The family of amplifiers integrates with most data acquisition programs. The pCLAMP™ 11 Software and DigiData® 1550B system for data acquisition and analysis provide optimal performance.

FAQ

What types of patch-clamp experiments can the Patch Clamp Amplifiers support?

The Patch Clamp Amplifiers supports the full range of patch-clamp configurations including whole-cell voltage-clamp, single-channel recordings, and two-electrode voltage-clamp. It is suited for both macroscopic current recordings and ultra-low-noise single-channel experiments in excitable cells.

What is the noise performance of the Patch Clamp Amplifiers?

The Patch Clamp Amplifiers is engineered for best-in-class signal-to-noise performance. The Axopatch 200B variant is specifically optimized for ultra-low-noise single-channel recordings, making it ideal for resolving small unitary conductances in ion channel research.

Is the Patch Clamp Amplifiers compatible with pCLAMP software?

Yes. The Patch Clamp Amplifiers is fully compatible with Axon pCLAMP software for data acquisition and analysis, communicating via the Digidata digitizer interface for seamless command voltage output and current signal acquisition.

Who are the primary users of the Patch Clamp Amplifiers?

The Patch Clamp Amplifiers is designed for neuroscientists, cardiac physiologists, and cell biologists who require precise membrane voltage control and current measurement. It is used in academic research, pharmaceutical screening, and ion channel characterization studies.