MOD-multiclamp700B

Patch Clamp Amplifiers

The Axon Instruments® series of amplifiers provide best-in-class solutions for the entire range of patch-clamp experiments. The portfolio of amplifiers includes Axopatch™ 200B for ultra low-noise single-channel recordings, MultiClamp™ 700B for whole-cell voltage-clamp and high-speed current-clamp recordings, and Axoclamp™ 900A for two-electrode voltage-clamp and current-clamp recordings.

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Patch-clamp amplifiers from single channels to large macroscopic recordings

The Axon Instruments^® series of amplifiers provide best-in-class solutions for the entire range of patch-clamp experiments. The portfolio of amplifiers includes Axopatch™ 200B for ultra low-noise single-channel recordings, MultiClamp™ 700B for whole-cell voltage-clamp and high-speed current-clamp recordings, and Axoclamp™ 900A for two-electrode voltage-clamp and current-clamp recordings.

Maximize signal to noise ratio

The Axopatch 200B Capacitor Feedback Patch Clamp Amplifier offers one of the lowest-noise single-channel recordings available via innovative capacitor-feedback technology.

Perform multi-channel experiments

The MultiClamp 700B Microelectrode Amplifier enables whole-cell voltage-clamp and current-clamp recordings. It is the most versatile amplifier in the portfolio.

Measure large currents

Large output compliance range of our Axoclamp 900A Microelectrode Amplifier facilitates the measurement of large and rapid voltage-clamp and current-clamp recordings.

Features

Actively cooled headstage

The Axopatch 200B amplifier features proprietary technology that provides active headstage cooling that reduces electrical noise close to the theoretical limits of physics.

Software control of settings

The MultiClamp 700B and Axoclamp 900A amplifiers offer software control. Software control streamlines setup, and enables automation of parameters, telegraphing, and advanced protocols.

Support up to four headstages

The MultiClamp 700B supports up to two primary CV-7B headstages and two optional auxiliary headstages (HS-2 or VG-2 type) enabling multi-channel recording for cellular network studies.

Large output compliance range

The Axoclamp 900A amplifier supports the measurement of larger currents and ensures faster clamp speed (±180 V in TEVC and HVIC modes).

Multiple modes of operation

The Axoclamp 900A amplifier offers 5 modes of operation: current clamp, discontinuous current clamp, two-electrode voltage clamp, discontinuous single-electrode voltage clamp, high-voltage current clamp.

Works with any data acquisition system

The family of amplifiers integrates with most data acquisition programs. The pCLAMP™ 11 Software and DigiData® 1550B system for data acquisition and analysis provide optimal performance.

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	Axopatch 200B Capacitor Feedback Patch Clamp AmplifierRequest a Quote	MultiClamp 700B Microelectrode AmplifierRequest a Quote	Axoclamp 900A Microelectrode AmplifierRequest a Quote
General specifications
Applications	Single-channel recording, whole-cell patch-clamp recording, extracellular recording, amperometry/voltammetry, bilayer recording, nanopore study	Single-channel recording, whole-cell patch-clamp recording, intracelluar sharp electrode recording, extracellular recording, amperometry/voltammetry, bilayer recording, nanopore study	Whole-cell current-clamp recording, intracelluar sharp electrode recording, extracellular recording, two-electrode voltage-clamp recording
Smart telegraph	Gain, filter, capacitance	Gain, filter, capacitance, input/output scaling factors, recording mode - 2 channels	Gain, filter, capacitance, input/output scaling factors, recording mode - 2 channels
Seal test	YES	YES	YES
Holding potential range	-/+ 1000 mV	-/+ 1000 mV	-/+ 200 mV for dSEVC and TEVC modes
Holding current range	-/+ 200 nA	-/+ 200 nA	Up to -/+ 1/Ro (feedback resistor)
Output gain (mV/pA)	0.5 to 500	1.0 to 2000	1.0 to 2000
Modes	I-Clamp, V-Clamp	I-Clamp, V-Clamp	I-Clamp, DCC, HVIC, dSEVC, TEVC
Open circuit noise in 5kHz and 10 kHz	0.06 pA rms, (5 kHz), 0.13 pA rms (10 kHz)	0.15 pA rms, (5 kHz), 0.28 pA rms (10 kHz)	NO
True voltage clamp-resistor feedback	YES for cSEVC	YES for cSEVC	YES for dSEVC
Capacitance Compensation	YES	YES	YES
RMS noise	0.13 pA rms (10 kHz) increases to only 0.145 pA RMS when a patch-pipette holder is attached	0.28 pA rms (10 kHz) at 50 GΩ to 3.0 pA rms (10 kHz) at 50 MΩ	20 mV at 10 kHz
Automatic oscillation suppression	NO	YES	YES
Automated mode-switching between current clamp and voltage clamp mode	NO	YES	YES
Slow current injection to maintain assigned potential	NO	YES	YES
True current clamp-voltage follower	NO	YES	YES
Simultaneous dual patch clamping recordings	NO	YES	YES
Computer control*	NO	YES	YES
Conventional interface	YES	YES	YES

Patch Clamp Techniques

MultiClamp700B Manual

Molecular Devices Patch Clamp Publications

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