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MUX Cross Chip Multiplexer Flow Matrix by Elveflow
The MUX Cross Chip is a 4×4 microfluidic valve matrix that connects any of 4 inputs to any of 4 outputs and provides true zero-flow stop conditions in 100 ms. PEEK valves with 10-32 fittings, software-controlled and TTL-triggerable, it eliminates residual Poiseuille flow during imaging or separation phases for reproducible, plug-and-play microfluidic experiments.
What is the MUX Cross Chip?
The MUX Cross Chip is a 4 × 4 microfluidic valve matrix from Elveflow. It lets you connect any of 4 inputs to any of 4 outputs by opening and closing valves in software — a unique routing capability that supports low-volume injections, sample premixing, and on-chip peristaltic pumping in a single plug-and-play instrument.
What sets the MUX Cross Chip apart is its "Zero Flow" function: a software-driven equilibrium that eliminates residual Poiseuille flow inside the chip in just 100 ms, giving you genuine stop-flow conditions during imaging or separation phases. By using a liquid buffer as a carrier and introducing samples through a T-junction or Elveflow chip holder, the matrix also enables controlled injection of very low volumes (under 10 µL).
Key Features
- 4 × 4 routing matrix: Connect any input to any output in software.
- True stop-flow in 100 ms: "Zero Flow" function eliminates residual Poiseuille flow for reproducible imaging.
- Low-volume injection: Controlled injection under 10 µL via T-junction or chip holder.
- PEEK valves: 10-32 UNF microfluidic fittings, chemically robust.
- Plug & play: Designed for fast setup with no plumbing complexity.
- Trigger I/O: TTL trigger in/out for synchronisation with microscopes and other instruments.
Applications
The MUX Cross Chip is built for protocols that demand precise routing and absolute stop-flow conditions. Common applications include:
- Sample premixing before chip entry.
- Fast medium switching for drug testing.
- On-chip peristaltic pumping.
- Sequential sample injection across multiple outputs.
- Cell or particle sample screening.
- Medium perfusion switching for cell biology.
- Diffusion studies with absolute stop-flow conditions.
- Unidirectional recirculation and organ-on-chip workflows.
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Technical Specifications
| Catalog Number | MUX-CROSS-CHIP |
| Valve type | 2/2-way NC solenoid valve |
| Number of valves | 16 (4 × 4 matrix) |
| Number of inlets / outlets | 2 inlets / 4 outlets (4 × 4 routing) |
| Response time | 20 ms per valve, 100 ms total stop-flow |
| Inlet / outlet connectors | 10-32 UNF |
| Wetted materials | PEEK / FKM / POM C |
| Casing | Aluminium, Rubber |
| Dimensions | 220 × 130 × 130 mm |
| Connection type | USB-B |
| Software & SDK | ESI, C++, Python, LabVIEW, MATLAB |
| Trigger | 1× TTL Trigger IN, 1× TTL Trigger OUT |
| Power supply | 100–240 VAC, 24 V DC |
Applications
- Sample premixing before microfluidic chip entry
- On-chip peristaltic pumping
- Sequential sample injection across multiple outputs
- Drug testing with fast medium switching
- Cell perfusion and organ-on-chip workflows requiring true stop-flow
- Diffusion studies with absolute equilibrium
Microfluidics
Explore All ProductsElveflow Publications
Academic publications and research studies utilizing Elveflow microfluidic instruments, sourced from Google Scholar.
What is the MUX Cross Chip Multiplexer Flow Matrix and what is it used for?
The MUX Cross Chip is a 4 × 4 microfluidic valve matrix by Elveflow that connects any of 4 inputs to any of 4 outputs in software. Its "Zero Flow" function eliminates residual Poiseuille flow inside the chip in 100 ms, making it ideal for sample premixing, low-volume injection, on-chip pumping, and imaging protocols that demand absolute stop-flow conditions.
What research applications is the MUX Cross Chip suited for?
The MUX Cross Chip is suited for sample premixing, fast medium switching in drug testing, on-chip peristaltic pumping, sequential sample injection, cell or particle screening, perfusion switching for cell biology, diffusion studies, unidirectional recirculation, and organ-on-chip workflows.
What are the key technical features of the MUX Cross Chip?
The MUX Cross Chip (catalog: MUX-CROSS-CHIP) integrates 16 PEEK valves in a 4 × 4 routing matrix with 20 ms valve response and 100 ms full stop-flow. It uses 10-32 UNF fittings, supports TTL trigger I/O, and offers full ESI / SDK control (C++, Python, LabVIEW, MATLAB) for plug-and-play integration.
Is the MUX Cross Chip available in Israel with local support?
Yes. NBT Ltd distributes Elveflow microfluidic products in Israel. Our team provides local support and application guidance for the MUX Cross Chip and the complete Elveflow microfluidic automation ecosystem.
How does the MUX Cross Chip integrate with Elveflow systems?
The MUX Cross Chip integrates with the Elveflow OB1 pressure controller for upstream flow generation and is fully orchestrated by ESI software, which lets you sequence valve routing alongside pressure profiles. TTL trigger I/O enables synchronisation with microscopes and third-party instruments for time-locked imaging or measurement protocols.
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