What is the Harvard Apparatus PHD ULTRA™ CP 4400?

The PHD ULTRA™ CP 4400 is the world's first syringe pump to combine constant pressure and constant flow operation in a single, versatile unit. By connecting to any standard 0–10 VDC pressure transducer or amplifier, the CP 4400 automatically regulates fluid delivery to maintain a user-defined pressure within ±2% — a critical requirement for pressure-sensitive applications where flow-rate-based control falls short.

Whether you are perfusing organs at physiological pressure, delivering fluids into the eye or body cavity under controlled resistance, or running microfluidic experiments that demand constant upstream pressure, the CP 4400 eliminates the need for external pressure regulators or manual adjustments. Built on the proven PHD ULTRA™ platform, it offers the same precision and programmability as the standard PHD Ultra while adding PID-controlled pressure feedback as a first-class operating mode.

Key Features

• Dual Mode Operation — Constant Pressure and Constant Flow: The CP 4400 uniquely supports both operating modes in a single pump. Switch between constant pressure and constant flow on the fly, making it adaptable to any experimental protocol without additional equipment.
• PID Pressure Feedback Control: Connects to any 0–10 VDC pressure transducer or amplifier for closed-loop pressure regulation, maintaining user-set pressure within ±2% across the full range of conditions.
• Exceptional Flow Range: Delivers from 3.06 pl/min up to 215.8 ml/min using a single syringe (0.5 µl to 140 ml), covering the full spectrum from nanoliter-scale microfluidics to large-volume organ perfusion.
• High Force Capacity: A maximum linear force of 200 lb ensures reliable operation with high-viscosity fluids, narrow-bore tubing, and resistance-heavy fluidic circuits.
• Intuitive 4.3" Colour Touchscreen: The WQVGA TFT touchscreen provides a clear, menu-driven interface for programming infusion/withdrawal sequences and entering pressure setpoints without requiring a PC.
• Broad Regulatory Approvals: Certified to CE, ETL (UL, CSA), WEEE, EU RoHS, and CB Scheme standards for use in laboratories worldwide.