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Conditioned Place Preference (CPP)
2- and 3-compartment place preference apparatus with interchangeable patterned floors and context walls for reliable contextual discrimination. Available in rat (42552) and mouse (42553) sizes; tethered versions (43552-D03/43553-D03) support optogenetics and electrophysiology.
Conditioned Place Preference (CPP)
The Ugo Basile Conditioned Place Preference (CPP) apparatus evaluates the motivational properties of rewarding or aversive stimuli by measuring an animal's preference for a context previously associated with that stimulus. Available in 2-compartment (Cat. 42552/42553) and 3-compartment models, the system features interchangeable patterned floors and textured walls for reliable contextual discrimination.
High-contrast, non-reflective finishes optimize the apparatus for video-tracking software. A 3-compartment model (Cat. 42552-D03/42553-D03) includes a neutral central chamber, and tethered versions (Cat. 43552-D03/43553-D03) support optogenetics and electrophysiology experiments.
Key Features
- 2- and 3-compartment models for rats and mice
- Interchangeable striped and checkered floors and walls
- High-contrast non-reflective finish optimized for video tracking
- Tethered animal versions for optogenetics/electrophysiology
- Rat 2-compartment: 63 × 32 × 35 cm; Mouse: 35 × 18 × 29 cm
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Research Applications
Conditioned Place Preference (CPP) is a fundamental assay for studying the rewarding and aversive properties of drugs, stimuli, and environmental contexts. It provides a non-contingent measure of drug reward, making it widely used in addiction research, as well as in studies of natural rewards and aversive conditioning.
- Addiction research: Measuring the rewarding properties of drugs of abuse (opioids, stimulants, cannabinoids)
- Drug aversion: Identifying aversive drug properties using conditioned place aversion paradigms
- Natural rewards: Assessing preference for food, social, or novel environment cues
- Optogenetics: Mapping reward circuits using tethered CPP apparatus with fiber optic stimulation
- Extinction and reinstatement: Modeling relapse and extinction of drug-seeking behavior
Technical Specifications
| Catalog Numbers | 42552 (rat 2-comp.), 42553 (mouse 2-comp.), 42552-D03 (rat 3-comp.), 42553-D03 (mouse 3-comp.) |
|---|---|
| Rat 2-Compartment Dimensions | 63 × 32 × 35 cm (H) |
| Mouse 2-Compartment Dimensions | 35 × 18 × 29 cm (H) |
| Rat 3-Compartment Dimensions | 81 × 33 × 32 cm (H) |
| Mouse 3-Compartment Dimensions | 45.4 × 16.2 × 32 cm (H) |
| Floor Patterns | 4 interchangeable patterns |
| Context Walls | 2 kits (striped/checkered) |
Memory and Learning
Explore All ProductsWhat does Conditioned Place Preference measure?
CPP measures the motivational (rewarding or aversive) properties of a drug, behavior, or context. Animals that associate a compartment with reward will spend more time there during a drug-free preference test.
What catalog numbers are available for the CPP apparatus?
2-compartment models: rat (42552), mouse (42553). 3-compartment models: rat (42552-D03), mouse (42553-D03). Tethered versions for optogenetics: 43552-D03/43553-D03.
How do the interchangeable floors and walls work?
The CPP apparatus includes 4 interchangeable floor patterns and 2 context wall kits (striped and checkered). Researchers swap floors and walls to create distinct contextual environments for each compartment.
Is the CPP apparatus compatible with optogenetics?
Yes — tethered animal versions (Cat. 43552-D03/43553-D03) accommodate fiber optic cannula and electrode cables for CPP experiments with simultaneous optogenetic stimulation.
What drugs or stimuli are commonly studied with CPP?
CPP is widely used to assess the rewarding properties of opioids, psychostimulants, cannabinoids, and alcohol, as well as natural rewards such as food, social interaction, and novelty.
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