Overview
The VF-800-0Z is designed for sectioning the tissue of larger animals. It is also the only vibratome that can section large organs without freezing. With a diameter of up to 100mm, it allows the brain sectioning of cats, dogs, pigs, and monkeys. Many neuroanatomy and neuropathology experiments require sectioning entire brains from these animals. The VF-800-0Z is capable of sectioning slices for these large primates down to 40 microns.
- Produces even, consistent slices (no more thick-and-thin sections)
- Slices over 5x faster than other market vibrating microtomes
- Patented compression technology and agarose embedding process tissue and eliminates chattermarks
- Auto Zero-Z® technology reduces Z-axis deflection to <4 μm
KEY FEATURES OF THE COMPRESSTOME® VF-800-0Z
The VF-800-0Z is the only large-size vibratome on the market. It can section human, non-primate, and whole organ systems. Check out its key features:
PROBLEMS WITH OTHER VIBRATOMES
There are many different types of tissue slicers on the market, but they don’t operate the way that the Compresstome® does. Other market vibratomes will have a flat stage where you glue your tissue sample, with a cutting blade that approaches horizontally. However, the blade can easily push your tissue sample and squish, tilt, and compress it—all of these effects may damage cells and tissue architecture.
BENEFITS OF SLIGHT COMPRESSION FOR TISSUE SLICING
When using the Compresstome®, you will embed your tissue in agarose inside a specimen tube. The open end of the specimen tube has a slightly tapered edge. As tissue and agarose cross the edge of the tube, it gets slightly compressed. This compression helps stabilize the tissue during sectioning, and allows the Compresstome® to section at speeds up to 5x faster than other market vibrating microtomes. Overall, the Compresstome® provides a significant improvement on the health and longevity of live slices, and virtually eliminates chattermarks in fixed tissue slices.
Don’t worry–The agarose embedding does not decrease cell viability. Rather, it enhances cell survival because of tissue stability. The agarose solution is quickly cooled down with a chilling block during sample preparation. With the Compresstome®, your tissue can be sectioned faster because of the agarose-induced stability. As a result, cells are never without oxygenation for a long time, and the added stability of the compression significantly reduces any blade damage.
DOWNLOAD AUTO ZERO-Z® EXPLANATIONS
WHAT IS AUTO ZERO-Z® TECHNOLOGY? HOW DOES IT BENEFIT TISSUE SLICING?
Compresstome® slicer models marked with “-0Z” mean that the model has our patented Auto Zero-Z® technology. These vibrating heads are precisely aligned to eliminate vibrations in the Z-axis. Auto Zero-Z® technology helps reduce damage to surface cells on live tissue samples, and further reduce chattermarks on thin sections for improved imaging results.
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