- Patented compression technology and agarose embedding process tissue and eliminates chattermarks
- Slices over 5x faster than other market vibrating microtomes
- Preserves surface neurons to significantly improve patch clamping results for electrophysiology
- Slice thickness ranging from 4μm-2000μm
- Produces free floating slices for better immunohistochemistry (IHC) – lmmunohistochemistry results
- Fully automated slicing, so no more tedious cryostat cranking
- Auto Zero-Z® technology reduces z-axis deflection to <1 μm
- Light footprint for increased portability
Benefits of Compression
![](https://precisionary.com/wp-content/uploads/2019/02/slight.jpg)
When using the Compresstome®, you will embed your tissue in agarose inside a specimen tube. The open end of the specimen tube has a slightly tapered edge. As tissue and agarose cross the edge of the tube, it gets slightly compressed. This compression helps stabilize the tissue during sectioning, and allows the Compresstome® to section at speeds up to 5x faster than other market vibrating microtomes. Overall, the Compresstome® provides a significant improvement on the health and longevity of live slices, and virtually eliminates chattermarks in fixed tissue slices.
Chattermarks
![](https://precisionary.com/wp-content/uploads/2019/02/300.jpg)
Above you can see the significant reduction in chattermarks in tissues slices produced with our Compresstome® VF-300-0Z versus sections made by another leading market vibratome.
Electrophysiology
![Cell_Viability_Graph Cell_Viability_Graph](https://precisionary.com/wp-content/uploads/2019/02/Cell_Viability_Graph-412x330.png)
- More than doubles the ratio of healthy-to-dead cells of acutely cut brain slices by preserving the upper surface layers of neurons.
- Preserves subcellular microstructure by stabilizing tissue samples during sectioning.
- Dramatically increases brain slice survival time in ACSF!
- The Compresstome® is ideal for getting healthy neurons for patch-clamp recording from mature mice (over 18+ months!). Check out www.brainslicemethods.com
Auto Zero-Z®
![](https://precisionary.com/wp-content/uploads/2019/01/AutoZeroZ_Flyer_Diagram1.jpg)
Compresstome® slicer models marked with “-0Z” mean that the model has our patented Auto Zero-Z® technology. These vibrating heads are precisely aligned to eliminate vibrations in the Z-axis. Auto Zero-Z® technology helps reduce damage to surface cells on live tissue samples, and further reduce chattermarks on thin sections for improved imaging results.