KWIK-SIL™ Low Toxicity Silicone Adhesive

KWIK-SIL is WPI’s gold-standard low-toxicity silicone adhesive for chronic neuroscience research. It cures in ~15 minutes at room temperature without generating heat, bonds reliably on live tissue, and withstands days of chronic study — the go-to choice for sealing craniotomies, securing implanted electrodes, and encapsulating peripheral nerves.

KWIK-SIL™ Low Toxicity Silicone Adhesive

What is KWIK-SIL?

KWIK-SIL is a translucent, medium-viscosity, two-part silicone adhesive developed by World Precision Instruments (WPI) for chronic peripheral nerve and neuroscience research. Packaged in a convenient double-barrel syringe with pre-mixing tips, it requires no preparation — simply apply directly to tissue and it self-cures at room temperature within minutes.

Unlike RTV silicones that take hours or days to cure, KWIK-SIL reaches working strength in approximately 15 minutes without generating heat, making it safe for use on live tissue and implanted devices. Its low toxicity formulation, strong mechanical properties, and reliable curing speed have made it a gold-standard adhesive in thousands of neuroscience labs worldwide.

Key Features

  • Low Toxicity Formulation: Based on a vinyl-terminated siloxane chemistry with no surfactant additives — far less toxic than dental silicones. The only curing by-product is a small amount of hydrogen gas, making it safe for in vivo and chronic applications.
  • Rapid, Heat-Free Cure: Cures in approximately 15 minutes at room temperature with a working time under 5 minutes. No heat is generated during curing, protecting delicate live tissue and sensitive implanted electronics.
  • Superior Mechanical Properties: Tear strength of 90 PPI and 650% elongation ensure the adhesive bond holds through days of chronic study without breaking, even with natural tissue movement.
  • Tissue-Resistant Chemistry: Unlike many vinyl-based silicones, KWIK-SIL is not inhibited by contamination from animal tissue, blood, or biological fluids — it cures reliably in the challenging conditions of live animal surgery.
  • Medium Viscosity: At 15,000 CPS, KWIK-SIL has sufficient body to stay where applied and seal around electrodes, cannulae, and probes without flowing into unwanted areas. This makes it ideal for sealing craniotomy windows and securing chronic implants.
  • Ready-to-Use Syringe Format: Pre-filled double-barrel syringe with 10 included mixing tips ensures automatic 1:1 mixing upon application — no manual preparation, no wasted material, no mixing errors.
  • Available Sterile: A sterile single-syringe version (KWIK-SIL-S) is available for applications requiring aseptic conditions, such as survival surgeries with implanted devices.
  • Hundreds Times Faster Than Standard RTV: Where conventional room-temperature-vulcanizing silicones cure in hours, KWIK-SIL reaches functional strength in minutes, dramatically reducing anaesthesia time and surgical risk.

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Technical Specifications

Catalog NumberKWIK-SIL
Sterile VersionKWIK-SIL-S (single syringe, sterile)
Mix Ratio1 : 1 (automatic via double-barrel syringe)
Working Time< 5 minutes
Setting Time (Room Temp.)5–10 minutes
Full Cure Time~15 minutes
Viscosity15,000 CPS
ColorTranslucent
Tear Strength (after 24 hrs)90 PPI
Elongation650%
Durometer (Shore A-2)30
Volume per Cartridge5 mL
Mixing Tips Included10
Shelf Life6 months at 23°C
Heat Generation During CureNone
Curing By-ProductsSmall amount of hydrogen gas only
ManufacturerWorld Precision Instruments (WPI)

Applications

  • Chronic peripheral nerve electrode implantation and recording
  • Cortical window and craniotomy sealing after probe or cannula implantation
  • Anterograde tracing with fluorescent indicators in peripheral nerve studies
  • Securing chronic EEG, LFP, or single-unit recording electrodes
  • Biocompatible encapsulation of optogenetic fibers and GRIN lenses
  • Wound closure and tissue sealing in survival surgeries
  • Live tissue encapsulation in acute and chronic biomedical experiments

KWIK-SIL silicone adhesive - double barrel syringe
KWIK-SIL-S sterile version being applied in neuroscience surgery

In Vivo Recording

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Peer-reviewed research using KWIK-SIL silicone adhesive

KWIK-SIL is cited widely in neuroscience literature for chronic electrode implantation, cortical window preparation, and peripheral nerve encapsulation. It appears in studies on in vivo electrophysiology, optogenetics, and long-term neural recording in rodent models.

What is KWIK-SIL and what is it used for in neuroscience research?

KWIK-SIL is a low-toxicity translucent silicone adhesive for chronic peripheral nerve and in vivo neuroscience studies. It seals craniotomies after electrode implantation, encapsulates peripheral nerves for recording, and secures chronic implants. Rapid room-temperature cure and tissue-safe formulation make it a standard in thousands of labs.

What is the difference between KWIK-SIL and KWIK-CAST?

KWIK-SIL is medium-viscosity (15,000 CPS) with strong mechanical properties for chronic implants that must hold for days. KWIK-CAST is very low viscosity, designed to flow around fine nerve structures for acute multi-fiber recordings. Choose KWIK-SIL for chronic studies, KWIK-CAST for acute nerve sealing.

How long does KWIK-SIL take to cure and is it safe for live tissue?

Working time under 5 minutes, full cure ~15 minutes at room temperature. No heat is generated during curing. The only by-product is a negligible amount of hydrogen gas. No surfactant additives, making it far safer than dental silicones.

Is KWIK-SIL available in Israel with local support?

Yes. NBT Ltd is the exclusive distributor of WPI products in Israel, providing full local support including ordering, application guidance, and technical assistance.

Is a sterile version of KWIK-SIL available?

Yes. KWIK-SIL-S is a sterile single-syringe version for survival surgeries and aseptic applications. Both versions use the same low-toxicity formulation with pre-mixing tips included.

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