What is the Compresstome® VF-800-0Z?

The Compresstome® VF-800-0Z is a large-diameter, fully automated vibrating microtome designed by Precisionary Instruments for sectioning large tissue specimens without freezing. It is the only vibratome on the market capable of accommodating samples up to 100 mm in diameter, making it the instrument of choice for whole-brain, large organ, and high-throughput multi-sample sectioning in preclinical and basic research settings.

The patented Compresstome technology uses a cylindrical agarose-embedding system that stabilizes tissue from the outside in, dramatically reducing compression artifacts and enabling consistent section quality across the full diameter of large specimens. With Z-axis vibration below 4 µm and full parameter control over advance speed, vibration frequency, and slice thickness, the VF-800-0Z delivers reproducible results whether you are preparing live acute brain slices for electrophysiology or fixed tissue for immunohistochemistry and electron microscopy.

Key Features

• Large-Diameter Sectioning: Accepts specimens up to 100 mm in diameter — primate brains, human organs, and multiple rodent brains simultaneously.
• No Freezing Required: Agarose embedding preserves tissue viability and morphology without cryodamage, enabling live-cell protocols.
• Sub-4 µm Z-Axis Vibration: Minimizes compression and tearing for clean, artifact-free sections as thin as 40 µm.
• Fully Automated Operation: Integrated control box with intuitive parameters for advance speed (0–5 mm/s), vibration frequency (0–60 Hz), and step thickness (1 µm resolution).
• 5× Faster Than Conventional Vibratomes: High-throughput design enables rapid production of large section series for histopathology, genomics, and organoid studies.
• Cordless Motor: Quiet, durable brushless motor with no cables obstructing access to the specimen tray.
• Tungsten Carbide Blade Compatibility: Custom-made blades deliver consistent cutting performance across soft and fixed tissues alike.