CMA 8 Microdialysis Probes

Ideal for use in small areas of the brain or spinal cord of small animals. First recommendation for studies in transgenic mice.

CMA 8 Microdialysis Probes
  • Extremely small
  • Optimized for CNS use
  • Ideal for chronic implantation
  • 20 kDa and 100 kDa membranes
  • Metal free and β-irradiated options available as custom made probes

The CMA 8 Microdialysis Probe is ideal for use in small areas of the brain or spinal cord of small animals. First recommendation for studies in transgenic mice.

The probe is small and lighter than the CMA 12 probes allowing the use of 20 kDa and 100 kDa membranes in mice.

An extremely small plastic body, where the inlet and outlet tubing are directly mounted, makes the probe easy to implant and light for a small animal to carry. A matching small and lightweight guide cannula is available.

CMA 8 Microdialysis Probes are guaranteed for single use.

Probe Name CMA 8 Elite CMA 8 High Cut-off
Membrane Material Cutoff PAES, 20k DA PES, 100k DA
Membrane Length 1 or 2 mm 1 or 2 mm
Membrane Diameter 0.5 mm 0.5 mm
Stainless Steel Shaft Diameter 0.4 mm 0.4 mm
Shaft Length 7 mm 7 mm
Inlet Internal Volume Negligible Negligible
Outlet Internal Volume 0.3 µL 0.3 µL

Animal Infusion

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CMA Microdialysis

Academic publications and research studies utilizing CMA microdialysis systems for in vivo neurochemical monitoring, sourced from Google Scholar.

What is the CMA 8 Microdialysis Probe used for?

The CMA 8 Microdialysis Probe is implanted into brain tissue to sample extracellular neurotransmitters and metabolites in freely moving rodents. It is widely used in neuropharmacology to measure in vivo neurochemical changes in response to drugs or behavioral stimuli.

What brain regions can be targeted with the CMA 8 probe?

The CMA 8 is available in multiple membrane lengths and is suitable for targeting a wide range of brain regions including striatum, hippocampus, prefrontal cortex, and hypothalamus, following standard stereotaxic coordinates.

What is the molecular weight cutoff of the CMA 8 probe membrane?

The CMA 8 probe membrane has a molecular weight cutoff that allows passage of small molecules such as amino acids, monoamines, and small peptides, while excluding larger proteins and cell debris from the dialysate.

Is the CMA 8 probe compatible with CMA infusion pumps and fraction collectors?

Yes. The CMA 8 is designed for use within the complete CMA microdialysis system, integrating with CMA pumps, tubing adapters, swivels, and fraction collectors for seamless, low-dead-volume in vivo sampling.

How long can the CMA 8 probe be used in a single implantation?

The CMA 8 probe is designed for acute experiments, typically used for several hours up to one day post-implantation. For chronic microdialysis requiring longer sampling periods, dedicated chronic probe designs are recommended.

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