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Von Frey Hairs (Semmes-Weinstein Set)
Von Frey Hairs (Semmes-Weinstein monofilament set) measure the paw withdrawal reflex for evaluating mechanical allodynia and cutaneous sensation. The set of 20 monofilaments spans 0.008 to 300 grams, providing a portable, non-invasive method for pain threshold determination.
Von Frey Hairs (Semmes-Weinstein monofilament set) are used to measure the paw withdrawal reflex when the mouse or rat paw is unexpectedly touched, for evaluating mechanical allodynia and cutaneous sensation levels. The popular non-invasive technique uses a set of 20 monofilaments with an ascending series of increasingly stiff filaments from 0.008 to 300 grams.
Research Applications
Von Frey Hairs (Semmes-Weinstein monofilaments) are the classic non-invasive tool for assessing mechanical allodynia and cutaneous sensation in rodent pain models. Widely used in models of neuropathic pain, diabetes, spinal cord injury, and inflammatory conditions, they provide a low-cost, portable method for threshold determination using the up-down testing method.
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| Feature | Detail |
|---|---|
| Set Size | 20 monofilaments |
| Force Range | 0.008 g to 300 g (ascending series) |
| Method | Semmes-Weinstein monofilament set |
| Design | Retractable filament — easy to carry and protected from damage |
| Clinical Use | Diagnose hyper- or hypo-aesthesia pathologies |
| Optional Accessory | Perforated platform for plantar surface stimulation |
Analgesia
Explore All ProductsVon Frey Hairs Publications
Ugo Basile Von Frey Hair sets (Cat. 37450) are cited in thousands of neuropathic pain, inflammatory pain, and allodynia studies across mouse and rat models. The 20-filament Semmes-Weinstein set enables logarithmic force-scale paw withdrawal threshold testing for mechanical sensitivity assessment.
How many filaments are in the Semmes-Weinstein set?
The set contains 20 monofilaments covering a force range from 0.008 g to 300 g in an ascending series.
What technique is used with Von Frey Hairs?
The up-down method (Dixon method) is the most common approach, using sequential filament application to calculate the 50% paw withdrawal threshold.
Are Von Frey Hairs reusable?
Yes, the retractable design protects the filaments from damage and allows repeated use. Replacement individual filaments are available.
Is an accessory platform available?
An optional perforated platform is available for convenient stimulation of the rodent plantar surface during testing.
What is included in the kit?
The kit includes 20 monofilaments in a portable carrying case, covering the complete Semmes-Weinstein range for comprehensive allodynia testing.
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