- True versatility
Works with any cell type, any patch-clamp configuration, and any type of ion channel from single-cell channel recordings to secondary ion channel screening.
- Complex perfusion protocols
Rapid solution exchange (low millisecond range) enables analysis of fast kinetics.
- Low compound consumption and reusable chip
Allows long experiments with less than 150 μl, minimizing compound and buffer consumption.
- Optimized for safety pharmacology
Enables long experiments and long exposure times. Optimized for sticky compounds and designed for cumulative dose-response.
- Maximized data quality
Numerous cells per chip. Multiple compounds analyses per chip. Full dose-response for every compound. Gigaseal recordings with superior experimental control.
The system includes a motorized scan stage with stage controller and a joystick, a syringe pump to drive the flow in the microfluidic chip, as well as the Dynaflow® Commander software. It fully integrates with most inverted microscopes.
A system contains:
1 – Dynaflow® Resolve Chip
The Dynaflow® Resolve chip has 16 microchannels and is composed of a glass microfluidic chip and a plastic interface forming the wells and the recording chamber. The chip is reusable and developed to reduce the risk for non-specific binding of “sticky compounds” and offering improved cost-efficiency through low compound consumption.
2 – Motorized Scan Stage with Stage Controller and Joystick
A motorized scan stage is used to automatically translate chip movements. It includes a stage controller and a joystick and it is controlled by the Dynaflow® Commander software.
3 – Syringe Pump
A easy setup syringe pump especially designed to drive the flow in the Dynaflow® Resolve chip.
4 – Dynaflow® Commander Software
The Commander software assures control and pre-programming of the movements of the scan stage. It synchronizes precision solution exchange with real time tagging of the acquired data. The Windows-based Dynaflow® Commander software allows a full control of experiments, including scan protocols, exposure times and instant protocol changes.
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