Benefits

  • True versatility

Works with any cell type, any patch-clamp configuration, and any type of ion channel from single-cell channel recordings to secondary ion channel screening.

  • Complex perfusion protocols

Rapid solution exchange (low millisecond range) enables analysis of fast kinetics.

  • Low compound consumption and reusable chip

Allows long experiments with less than 150 μl, minimizing compound and buffer consumption.

  • Optimized for safety pharmacology

Enables long experiments and long exposure times. Optimized for sticky compounds and designed for cumulative dose-response.

  • Maximized data quality

Numerous cells per chip. Multiple compounds analyses per chip. Full dose-response for every compound. Gigaseal recordings with superior experimental control.

The System

The system includes a motorized scan stage with stage controller and a joystick, a syringe pump to drive the flow in the microfluidic chip, as well as the Dynaflow® Commander software. It fully integrates with most inverted microscopes.

Dynaflow Resolve System with numbers

A system contains:

1 – Dynaflow® Resolve Chip

The Dynaflow® Resolve chip has 16 microchannels and is composed of a glass microfluidic chip and a plastic interface forming the wells and the recording chamber. The chip is reusable and developed to reduce the risk for non-specific binding of “sticky compounds” and offering improved cost-efficiency through low compound consumption.

View Dynaflow Resolve Chip Specifications >>

2 – Motorized Scan Stage with Stage Controller and Joystick

A motorized scan stage is used to automatically translate chip movements. It includes a stage controller and a joystick and it is controlled by the Dynaflow® Commander software.

3 – Syringe Pump

A easy setup syringe pump especially designed to drive the flow in the Dynaflow® Resolve chip.

4 – Dynaflow® Commander Software

The Commander software assures control and pre-programming of the movements of the scan stage. It synchronizes precision solution exchange with real time tagging of the acquired data. The Windows-based Dynaflow® Commander software allows a full control of experiments, including scan protocols, exposure times and instant protocol changes.

Applications

More information about:

Properties of the 5HT3 receptor >>

P2X currents in DRG neurons >>

Sophisticated Characterization of P2X7 Antagonists >>

hKv4.3 antiarrhythmic compound inhibition >>

NMDA currents in acutely isolated neurons >>

Structure analysis of KATP channel >>

Manufacturer

Publications with DYNAFLOW® RESOLVE SYSTEM

Request for Quote

Please fill in as much details as possible and we will take care of your request as soon as possible

*Required field

Submit recaptcha - 3/3/19 */ ?>