• Target single cells

Target just one or a small number of adherent cells to particular compounds, e.g. drugs or antibodies, without diffusion outside the experimental region of interest. The compound can easily be confined.

  • Rapid delivery

Deliver four different compounds to just a single cell or part of a cell with sub-second exchange time.

  • Low compound consumption

The four integrated wells containing less than 35 μl, overcome typical dead volume problem of external tubing, reducing significantly the use of expensive reagents.

  • Combination with other probing devices

The pipette tip has been optimized to fit into practically any micromanipulation environment allowing combination with other probes such as patch-clamp pipettes, optical fibers or electrodes.

  • No glass or tip breakage

The pipette tips are made from a flexible biocompatible material so that unlike glass pipettes they won’t break upon contact with the hard surface.

  • No contamination

The pipette tip has been developed from an hydrodynamically confined flow principle, enabling contamination-free confinement of one miscible liquid inside another.

BioPen® PRIME and BioPen® FLEX Systems are comprised of a high precision pressure controller, a disposable pipette tip inserted in a holder and, PC software. They integrate with common micromanipulators and microscopes.

The System

BioPen PRIME System

A system contains:

1 – Disposable pipette tip: 

The pipette tip is used to deliver up to 4 different compounds. The pipette tip is made from a flexible medical grade elastomer material so that unlike glass pipettes it won’t break upon contact with a hard surface. It includes 8 wells; 4 wells for containing compounds and 4 wells for collecting waste. Each well can contain up to 35 μl of drugs. Two types of tips are available: PRIME and FLEX.

Discover BioPen PRIME and FLEX Pipette tips >>

New  Sterile PRIME and FLEX pipette tips are now available!

2 – Pressure Controller:

Two levels of pneumatic pressure are supplied by the pressure controller and fast solution switching is achieved through the use of miniature solenoid valves.

3 – Pipette holder:

The pipette holder is a pressure manifold to assure a closed system and to connect each solution reservoir of the pipette tip individually with the precision pressure controller. It has been designed to be compatible with any standard type of micromanipulator such as, for example, the PatchStar from Scientifica. Two types of pipette holders are available: PRIME and FLEX.

Discover BioPen PRIME and FLEX Pipette Holders >>

4 – Software:

The software enables facile configuration and use of the BioPen® system. The Windows-based BioPen® software allows independent control of each pressure line and compounds delivery. It also includes a scripting module for automation of common tasks and setup/shutdown.


Find the best BioPen System for your application needs >>


Prime and Flex



  • Pipette tips specifications

View BioPen FLEX Tip Specifications >>

View BioPen PRIME Tip Specifications >>

  • Pipette holders specifications

View Pipette Holder FLEX Specifications >>

View Pipette Holder PRIME Specifications >>

  • Pressure controller specifications

View BioPen Pressure Controller Specifications >> 


Learn more about BIOPEN® SYSTEMS

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